EIA-AFP

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Alkor Bio, Ltd.

Business Type:Manufacturer

Country/Region:Russia

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8/10

Product Information

  • Certification:CE
  • Warranty:1 year

Description

Alfa-fetoprotein (AFP) is a glycoprotein with a molecular weight of about 70 000 Da. During the ontogenesis AFP is produced mostly in yolk-sac and embryonic liver and, in less extent, in gastrointestinal tract. AFP is the main serum protein of early fetus. AFP concentration in fetal serum reaches its pick point of up to 240 000 IU/ml between 12 and 15 weeks of gestation. Then its concentration decreases and at the end of second year reaches the normal level (0-16 IU/ml). Normally AFP concentration remains at this level for rest of the life. 

AFP is excreted from fetus’s kidneys into the amniotic fluid. From there it penetrates into maternal blood through placenta and umbilical cord. AFP level in serum of pregnant women continuously increases and reaches the maximum (up to 400 IU/ml) at the middle of the third trimester. The serum level of AFP measurement in pregnant women is an important method of early diagnosis of some inborn diseases (such as Down’s syndrome). Besides, this method is widely used in obstetrics for diagnosis of multiple pregnancy, prenatal death and risk of abortion. AFP measurement can be also used for the diagnosis and monitoring of different forms of cancer. For instance, high and persistent AFP level (800…80 000 IU/ ml) is often connected with primary hepatomas, testis teratomas and ovary tumors. 

EIA-AFP kit is intended for the quantitative determination of alpha-fetoprotein in human serum.


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